研究方向：心血管和神经药理。

   研究领域：围绕细胞焦亡在疾病中的作用，发现新药物以及探索各信号通路发挥的作用及机制。

1.国家自然科学基金委员会, 地区科学基金项目, 82360786, ：基于NLRP3炎性小体驱动的巨噬细胞焦亡研究穗花杉双黄酮抗动脉粥样硬化作用, 2024-01-01 至 2027-12-31, 32万元, 在研, 主持
       2.贵州省科技厅，贵州省科技计划项目，黔科合基础-ZK[2022]一般625，穗花杉双黄酮通过NLRP3炎症小体介导的巨噬细胞极化抗动脉粥样硬化的作用及机制研究2022-04至2025-03,10万元，在研，主持
       3.贵州省卫生健康委员会, 2021年度委科学技术基金项目, gzwkj2021-467, 穗花杉双黄酮对Ox-LDL诱导的巨噬细胞焦亡的作用及机制初探, 2021-08 至 2023-12, 2万元, 结题, 主持
       4.遵义市科技局, 遵义医科大学2020年科学技术联合资金项目, 遵市科合HZ字（2020）71号, 基于Nrf2/ARE信号通路探讨绿原酸酰胺类似物对PC12细胞氧化应激损伤的保护机制, 2020-10 至 2023-10, 2万元,结题, 主持

5.遵义医科大学，2017年度学术新苗培养及创新探索专项项目培育项目，黔科合平台人才（[2017]5733-048),金银花提取物对D-半乳糖模型和LPS模型小鼠认知障碍的改善作用及机制探究，2019-10至2022-10,10万元，结题，主持

1. Lei Zhu; Zhonghua Shi, Huichuan Luo, Shuqi Wang, Maojun, Dai, Qiang Huang*. Development and evaluation of a novel chlorogenic acid analogue with enhanced antioxidant activity in vitro. Journal of Molecular Structure, 2025, 1341:142626.

2. Lei Zhu; Xiaojie Hou; Xiaohang Che; Tingshuo Zhou; Xiaoqi Liu; Chunfu Wu*; Jingyu Yang* ;Pseudoginsenoside-F11 attenuates cognitive dysfunction and tau phosphorylation in sporadic Alzheimer's disease rat model, Acta Pharmacologica Sinica, 2021, 42(9):1401-1408.

3. Lei Zhu; Zhen Zhang; Xiaojie Hou; Yongfeng Wang; Jingyu Yang*; Chunfu Wu* ; Inhibition of PDE5 attenuates streptozotocin-induced neuroinflammation and tau hyperphosphorylation in a streptozotocin-treated rat model, Brain Research, 2019, 1722: 146344.

4. Lei Zhu; Jingyu Yang; Xue Xue; Yingxu Dong; Yang Liu; Fengrong Miao; Yongfeng Wang; Hong Xue*; Chunfu Wu* ; A novel phosphodiesterase-5 Inhibitor: Yonkenafil modulates neurogenesis, gliosis to improve cognitive function and ameliorates amyloid burden in an APP/PS1 transgenic mice model, Mechanisms of Ageing and Development, 2015, 150: 34-45.

5. Boyu Liu, Lei Zhu, Lei Lei, Huifang Li, Rui Cong, Jinfan Hou, Jiehui Zhao, Pengwei Li, Yiwei Tang, Zhigui Su*, Jiasheng Tu* and Lei Jiang*. Lesional Macrophage-Targeted Nanomedicine Regulating Cholesterol Homeostasis for the Treatment of Atherosclerosis. Adv Mater. 2025 Jun 27:e2502581.

6. Weiwei Li; Dan Li; Yao Qin; Chengxin Sun; Yongling Wang; Lei Gao; Lang Linghu; Feng Zhang; Wen Cai; Lei Zhu*; Gang Wang* ; Cardioprotective effects of Amentoflavone by suppression of apoptosis and inflammation on an in vitro and vivo model of myocardial ischemia-reperfusion injury, International Immunopharmacology, 2021, 101(PtB):108296.

7. Hang Zhang; Yin-mei Ban; De-mei Li; Gang Wang; Juan Gu; Lei Zhu*; Amentoflavone for treating cardiocerebrovascular diseases and neurological disorders, Frontiers in Pharmacology, 2024, 15: 1406510.

8. Hang Zhang; Tian Zhao; Juan Gu; Fushan Tang*; Lei Zhu*; Gut microbiota and inflammasomemediated pyroptosis: a bibliometric analysis from 2014 to 2023, Frontiers in Microbiology, 2025, 15: 1413490.