1.有机合成方法学

2.新型生物活性多肽分子的设计、合成和体内活性研究

[1] Yang J, Zhang M, Ban Y, Hou Z, Xiao X, Yao Q* and Huang, Y.* Nickel-Catalyzed Hydrocyanoalkylation of Terminal Alkynes: A Route to Tetrasubstituted (Z)-Alkenyl Nitriles. Org. Lett. 2026, 28, 2753. (SCI 1区， IF 5.0)

[2] Guo X,^# Pu G,^# Xiao L, Liang J, Zhang H, Chen Y, Huang Y,* Yao Q* and He C-Y.* EtAlCl2 -Promoted Defluorinative Thiolation of α-Trifluoromethyl Alkenes. Org. Chem. Front. 2026, 10.1039/D6QO00011H.

[3] Huang Y^#, Wu C^#, Lu A^#, Wang J, Liang J, Sun H, Yang L, Duan S, Berezin A, Wu C, Zhang B, Wu Y-L* and Tsai Y-H*. A single bioorthogonal reaction for multiplex cell surface protein labeling. J. Am. Chem. Soc., 2025, 147, 1612.（SCI 1区，IF 15.6）

[4] Huang Y, Jia J, Huang Q-P, Zhao L, Wang P, Gu J. and He C-Y*. Visible light promoted deaminative difluoroalkylation of aliphatic amines with difluoroenoxysilanes. Chem. Commun., 2020, 56, 14247.（SCI 1区，IF 6.2）

[5] Zhao L*^#, Huang Y.^#, Wang Z, Zhu E, Mao T, Jia J, Gu J, Li X-F* and He C-Y*. Organophosphine-Catalyzed Difluoroalkylation of Alkenes. Org. Lett., 2019, 21, 6705.（SCI 1区，IF 6.0）

[6] Huang Y, ^# Lei Y-Y, ^# Zhao L, Gu J, Yao Q, Wang Z, Li X-F*, Zhang X* and He C-Y*. Catalyst-free and visible light promoted trifluoromethylation and perfluoroalkylation of uracils and cytosines. Chem. Commun., 2018, 54, 13662.（SCI 1区，IF 6.16）

[7] Huang Y, Wang A-J, Kong J, Lou Y-G, Li X-F* and He C-Y*. Efficient difluoromethylation of isoflavonoids and flavonoid under mild conditions. Synth. Commun., 2017, 48, 91. (SCI 4区，IF 1.13)