一、近5年主持的代表性科研项目

1. 国家自然科学基金：基于“肝脾同调”研究蓝布正的补血效应及作用机制（编号：81560736，2016年1月-2019年12月），37万元。

2. 国家自然科学基金青年项目：斑蝥素致肾毒性的生物标志物及毒理机制研究（编号：81803838编号：82060754，2019年1月-2021年12月），21万元。

3. 国家自然科学基金地区基金项目：基于“脂质标志物-代谢通路-关键代谢酶”探究斑蝥素致肝损伤的分子机制（编号：82060754，2021年1月-2024年12月），34万元。

4. 贵州省科技重大专项（贵州金钗石斛、铁皮石斛开发利用共性关键技术研究及产业化）子课题：贵州金钗石斛产地加工与炮制技术集成化研究及应用示范（编号：黔科合重大专项[2015]6010-1），2015年1月-2018年12月，70万元。

5. 名贵中药资源可持续利用能力建设项目：基于“成分-功效-毒性”整合策略的斑蝥资源的评价体系研究（编号：2060302-1907-06，2019年09月-2022年12月），15万元。

6. 贵州省优秀青年科技人才计划（编号：黔科合平台人才-YQK[2023]038），2023年5月-2026年4月，20万元。

7.  贵州省科技厅重点项目：Nrf2和NF-κB信号通路交互作用在斑蝥素肾损伤中的作用及机制研究（编号：黔科合基础-ZK[2025]重点054，2025年1月-2028年12月），20万。

二、近5年授权专利

     1. 张建永，杨沙，赵茹茹，陈衬心，许朋。蓝布正总鞣质的制备方法及应用。遵义医科大学，授权号：ZL201811079 304.6（转让，5万元，贵州科倍安生物制药有限公司）

2. 段灿灿，田鑫，张建永，李尧，冯文忠。一种赤水金钗石斛花指纹图谱构建及其含量测定方法，授权号：ZL202111361363.4，2023年

3. 段灿灿，田鑫，张建永，李尧，冯文忠。赤水金钗石斛花成分含量测定方法，授权号：ZL202111361335.2，2023年

三、近5年获得科研奖励

1. 张建永，王岚，梁日欣，杨滨，基于网络药理学分析丹参山楂组分配伍抗动脉粥样硬化的作用机制，获中国中医科学院2015-2019年最具影响力优秀中文学术论文

2. 张建永，周旭美、赵梦、孟灵巍、周丽梅、徐艳、李玲. 药学创新性硕士研究生培养体系的构建和探索，遵义医科大学研究生教学成果三等奖，2021

3. 龚其海、袁泽利、张建永、高健美、李利生. “二三六”主导式地方院校药学研究生人才培养探索与实践，遵义医科大学，贵州省研究生教学成果一等奖，2021

4. 张建永，段灿灿，梅丽萍，李明，王晓宁. 贵州省药学科学技术奖三等奖. 贵州特色苗药单方蓝布正综合开发的关键技术研究与产业化应用。杭州佗鹊堂生物科技有限公司、贵州科倍安生物制药有限公司，2022年

5. 何芋岐，石京山，鲁艳柳，白朝钧，肖世基，张建永，杨继勇，陈集双，杨洲.贵州医学科技奖一等奖. 贵州道地药材金钗石斛优势物质基础及品质挖掘推动乡村振兴产业示范，2022年

 

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[3]Yi-Xin Zhang, Xiao-Fei Li*, Jian-Yong Zhang*.Pharmacological properties and mechanisms of ginsenoside Rg1 against acute kidney injury. Traditional Medicine Research 2025;10(6):35.（中科院4区，IF=0.9）

[4]Qiyi Wang, Weina Cheng, Tianmu He, Shan Li, Jingwen Ao, Yanmei He, Cancan Duan, Xiaofei Li, Jianyong Zhang*.Glycerophospholipid metabolic disorders and gender difference of cantharidin-induced hepatotoxicity in rats: Lipidomics and MALDI mass spectrometry imaging analysis[J].Chemico-Biological Interactions, 2025; 405: 111314.（中科院2区，IF=4.7）

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[9]Xiaotong Duan, Jingwen Ao, Ming Yu, Sali Li, Xiaofei Li*, Jianyong Zhang*. Shuganning Injection Suppresses Apoptosis for Protecting Against Cantharidin-Induced Liver Injury by Network Pharmacology and Experiment Validation[J]. ACS Omega. 2024, 9(12):13692-13703.(中科院3区，IF=4.1)

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[11] Wenbi Mu，Cancan Duan，Jingwen Ao，Fanpan Du，Jianyong Zhang*.TMT-based proteomics analysis of the blood enriching mechanism of the total Tannins of Gei Herba in mice[J].Heliyon, 2024, 10(12).DOI:10.1016/j.heliyon.2024.e33212. （中科院3三区，IF=3.4）

[12]Tang FY, Ma RY, Xiong AY, Lin SC, Wang X, Dong HJ*, Zhang JY*. Functional metabolomics analysis of the protective mechanism of total flavonoids of Scutellaria baicalensis on acute myocardial ischemia rats. Tradit Med Res. 2025;10(3):15. （中科院4区，IF=0.9）

[13]Lin K, Xiong L, Zhang W, Chen X, Zhu J, Li X*, Zhang J*. Exploring the pharmacological mechanism of fermented Eucommia ulmoides leaf extract in the treatment of cisplatin-induced kidney injury in mice: Integrated traditional pharmacology, metabolomics and network pharmacology. J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Nov 5;1248:124358. doi: 10.1016/j.jchromb.2024.124358（中科院3区，IF=2.8）

[14]Qing He, Kun Pang, Lin Tian, Yiqian Ma, Xiang Guo, Jianyong Zhang*, Ming Yu*. Melamine-Derived Mesoporous Carbon for Efficient and Selective Removal of Trace Hg(II) from Honeysuckle Decoction[J]. ACS omega, 2024; 9(45):44931-44941.（中科院3区，IF=4.1）

[15]Yaya Fan, Lin Chen, Qiuyi Jing, Xiaoli Li, Hong Pan, Chao Fang, Jianyong Zhang*, Fuguo Shi*. Covalent Binding of Reactive Anhydride of Cantharidin to Biological Amines[J].Drug metabolism and disposition: the biological fate of chemicals, 2024; 52(8):775-784.（中科院3区，IF=4.4）

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[19]Qi-yi Wang, Bing-bing Shan, Wei-na Cheng, Tian-mu He, Kuan Chen, Jian-yong Zhang*,Can-can Duan*. Metabolomics Study of the Hepatoprotective Effects and Mechanism of

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[20]Wang Y, Cheng W, Wang X, He T, Liu J, Chen S, Zhang J*. Integrated metabolomics and network pharmacology revealing the mechanism of arsenic-induced hepatotoxicity in mice[J]. Food and Chemical Toxicology. 2023, 20:113913. (中科院3区，IF:4.3)

[21]He T, Wang Q, Ao J, Chen K, Li X, Zhang J*, Duan C*. Endoplasmic reticulum stress contributes to autophagy and apoptosis in cantharidin-induced nephrotoxicity[J]. Food and Chemical Toxicology,2022,163:112986.(中科院2区，IF:5.572，TOP期刊)

[22]He T, Liu J, Wang X, Duan C, Li X*, Zhang J*. Analysis of cantharidin-induced nephrotoxicity in HK-2 cells using untargeted metabolomics and an integrative network pharmacology analysis[J]. Food and Chemical Toxicology. 2020,146:111845.(中科院1区，IF:6.025，TOP期刊)

[23]Yang Sha, Wang Xiaoning , Duan Cancan*, Zhang jianyong*. A novel approach combining metabolomics and molecular pharmacology to study the effect of Gei Herba on mouse hematopoietic function[J]. Biomedicine & Pharmacotherapy, 2020, 129:110437.(中科院2区，IF:6.530)

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