万南微，中共党员，博士，教授，博士研究生导师。博士毕业于浙江工业大学，师从中国工程院院士郑裕国教授，2016年进入遵义医科大学工作。现任贵州省生物催化与手性药物合成重点实验室副主任，贵州省绿色制药工程研究中心主任。研究方向为绿色生物催化制药技术的开发与合成应用，重点研究卤醇脱卤酶催化新反应机制及多样性合成。先后入选贵州第四批千人创新创业人才，贵州省省管专家，遵义市市管专家。先后获贵州省科技进步奖一等奖、贵州省研究生教学成果奖特等奖和贵州省高等教育教学成果一等奖各一项。先后主持国家级科研项目4项，主持成果转化3项，以通讯作者在Nature Communications、Angewandte Chemie International Edition、ACS Catalysis等期刊上发表SCI论文20余篇。

联系方式: 564879895@qq.com; nanweiwan@zmu.edu.cn

代表性科研项目

（1）国家自然科学基金，面上项目，22577170，卤醇脱卤酶催化对映体汇聚合成手性邻二醇的反应机制及合成应用研究，2026-01-01至2029-12-31，50万元，在研，主持

（2）国家自然科学基金，地区基金，22167023，卤醇脱卤酶催化C-N键构建新策略的定向调控及其催化机制的研究，2022-01-01至2025-12-31，36万元，在研，主持

（3）国家自然科学基金，青年基金，31800663，卤醇脱卤酶不对称环化反应机制的研究，2019-01-01至2021-12-31，24万元，结题，主持

（4）国家自然科学基金，地区基金，21662050，卤醇脱卤酶的筛选与改造及其在合成手性噁唑烷酮类化合物中的应用研究，2017-01-01至2020-12-31，40万元，结题，主持

（5）遵义医科大学未来“科技菁英”人才培养计划，ZYSE-2022-03，2023-01-01至2027-12-31，210万元，在研，主持

代表性科研成果

(10) Xia^# Hua, Yuan-Fei Wang^#, Xiao Jin, Hong-Yin Yu, Hui-Hui Wang, Yong-Zheng Chen, and Nan-Wei Wan*. Biocatalytic enantioselective formation and ring-opening of oxetanes. Nature Communications, 2025, 16(1), 1170.

(9) Run-Ping Miao, Hai-Xia Zhang, Kui-De Lu, Tong-Qiu Lu, Hui-Hui Wang, Yong-Zheng Chen, and Nan-Wei Wan*. Biocatalytic Efficient and Enantiocomplementary Synthesis of 3-Hydroxy-3-hydroxymethyloxindoles by Combining Halohydrin Dehalogenase and Epoxide Hydrolase. ACS Catalysis 2025, 15(2), 992-1001.

(8) Hong-Kang Fu, Tong-Qiu Lu, Ming-Cheng Zuo, Xin-Yu Da, Hui-Hui Wang, Yong-Zheng Chen, and Nan-Wei Wan*. Artificial biocatalytic cascades for the enantiocomplementary synthesis of 3-hydroxy- γ-butyrolactones. Green Chemistry, 2025, 27, 10194−10204.

(7) Jin-Mei Ma^#, Yuan-Fei Wang^#, Run-Ping Miao, Xiao Jin, Hui-Hui Wang, Yong-Zheng Chen, and Nan-Wei Wan*. Biocatalytic Construction of Spiro-Oxazolidinones via Halohydrin Dehalogenase-Catalyzed Ring Expansion of Spiro-Epoxides. ACS Catalysis, 2024, 14(14), 10670−10678.

(6) Xiao-Ying Zhou^#, Yuan-Fei Wang^#, Hong-Kang Fu, Hui-Hui Wang, Yong-Zheng Chen, and Nan-Wei Wan*. Biocatalytic Regio- and Enantiocomplementary Synthesis of Chiral Aryloxazolidinones. Advanced Synthesis & Catalysis, 2024, 366(11): 2461– 2467.

(5) Xue-E Guan, Run-Ping Miao, Xia Hua, Xiao Jin, Guo-Zhong Deng, Bao-Dong Cui, Wen-Yong Han, and Nan-Wei Wan*, and Yong-Zheng Chen*. Biocatalytic Enantioselective Synthesis of Chiral β‑Hydroxy Nitriles Using Cyanohydrins as Cyano Sources. ACS Catalysis, 2023, 13(20), 13597−13606.

(4) Zhu-Xiang Wang, Hong-Kang Fu, Xin-Yu Da, Hui-Hui Wang, Bao-Dong Cui, Wen-Yong Han, Yong-Zheng Chen,* and Nan-Wei Wan*. Biocatalytic Synthesis of Metaxalone and Its Analogues. Organic Letters, 2023, 25, 5049-5054.

(3) Ran Ma^#, Xia Hua^#, Cheng-Li He, Hui-Hui Wang, Zhu-Xiang Wang, Bao-Dong Cui, Wen-Yong Han, Yong-Zheng Chen,^* and Nan-Wei Wan^*; Biocatalytic Thionation of Epoxides for Enantioselective Synthesis of Thiiranes, Angewandte Chemie International Edition, 2022, 61(52), e202212589.

(2) Qin Xu,^# Kai-Shun Huang,^# Yuan-Fei Wang, Hui-Hui Wang, Bao-Dong Cui, Wen-Yong Han, Yong-Zheng Chen,^* and Nan-Wei Wan^*; Stereodivergent Synthesis of Epoxides and Oxazolidinones via the Halohydrin Dehalogenase-Catalyzed Desymmetrization Strategy, ACS Catalysis, 2022, 12(11): 6285−6293.

(1) Fang-Rui Zhang, Nan-Wei Wan*, Jin-Mei Ma, Bao-Dong Cui, Wen-Yong Han, and Yong-Zheng Chen*; Enzymatic Kinetic Resolution of Bulky Spiro-Epoxyoxindoles via Halohydrin Dehalogenase-Catalyzed Enantio- and Regioselective Azidolysis, ACS Catalysis, 2021, 11(15): 9066-9072.