秦磊,博士,副研究员。博士毕业于江南大学,2024年进入遵义医科大学工作。研究方向为生物酶的挖掘、改造及其在手性药物中间体的绿色制备,重点研究酮还原酶、P450酶及ThDP依赖酶催化新反应机制及多样性合成。以第一作者在Chemical Communications、Advanced Synthesis & Catalysi、Catalysis Science & Technology等期刊上发表SCI论文5余篇。
联系方式: 673043727@qq.com; lqin@zmu.edu.cn
近五年代表性科研项目
(1)贵州省教育厅青年科技人才成长项目-新型单胺氧化酶的挖掘及其在手性胺类化合物的合成研究, 2018-11-01-2021-10-30, 结题,主持;
(2)江苏省研究生科研与实践创新计划项目-羰基还原酶催化含N环状手性醇的不对称合成及调控研究,2020-04-01-2022-04-01, 结题,主持。
(3)遵义医科大学校内博士后培养项目-单胺氧化酶催化环胺的选择性调控机制与合成应用,2024-10-1-2028-10-1,在研,主持。
近五年代表性科研成果
(1) Lei Qin; Xin Su; Jun Wang; Lunjie Wu; Man Zou; Jie Gu; Yan Xu; Yao Nie; Regulating the stereoselectivity of medium-chain dehydrogenase/reductase by creating an additional active pocket accommodating prochiral heterocyclic ketones, Chemical Communications, 2023, 59: 13042-13045.
(2) Lei Qin; Xin Su; Jun Wang; Lunjie Wu; Man Zou; Jie Gu; Yan Xu; Yao Nie; Enantioselective regulation of short-chain dehydrogenases via key sites in its loop and adjacent regions for the enantiodivergent reduction of difficult-to-reduce ketones, Advanced Synthesis & Catalysis, 2023, 365: 4205-4215.
(3) Lei Qin; Lunjie Wu; Yao Nie; Yan Xu; Biosynthesis of chiral cyclic and heterocyclic alcohols via C=O/C–H/C–O asymmetric reactions, Catalysis Science & Technology, 2021, 11(8): 2637-2651.
(4) Lei Qin; Guozhong Deng; Lei Du; Baodong Cui; Nanwei Wan; Yongzheng Chen; Deracemisation of racemic 2-substituted indolines by monoamine oxidase from Pseudomonas monteilii ZMU-T01, Tetrahedron Letters, 2022, 113: 154249-154251.
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